Optimizing Outcomes in The Management of Multidrug-Resistant Gram-Negative Bacterial Infections
Release Date: 28 January, 2026
Expiration Date: 28 January, 2027
Activity Overview
This activity equips clinicians to diagnose and manage MDR gram-negative infections using real-world cases, rapid diagnostics, and evidence-based antimicrobial selection across acute care settings.
Target Audience
Infectious disease specialists, critical care specialists, nurse practitioners, hospital pharmacists, and clinical microbiologists.
Learning Objectives
Upon completion of the educational activity, participants should be able to:
● Demonstrate how to incorporate rapid and molecular diagnostic results into early treatment decisions for multidrug-resistant Gram-negative bacterial (MDR-GN) infections.
● Apply case-based algorithms to select targeted therapy based on diagnostic outcomes
● Explain the impact of rapid diagnostic turnaround time and accuracy on antimicrobial prescribing and stewardship outcomes
● Identify scenarios where rapid diagnostics can prevent unnecessary broad-spectrum antibiotic use
● Calculate AUC and Cmax for selected antimicrobials using clinical case data
● Adjust dosing regimens based on PK parameter interpretation to optimize efficacy and safety
● Apply PK/PD principles to tailor antibiotic dosing strategies according to bacterial strain, infection site, and patient immune status in order to optimize clinical outcomes
● Describe PK/PD targets relevant to different antibiotic classes and their role in maximizing treatment success
● Select optimal dosing strategies using PK/PD targets for MDR-GN infections in simulated cases
● Adjust antimicrobial regimens for elderly, obese, and organ-impaired patients using PK/PD principles
Expiration Date: 28 January, 2027
Activity Overview
This activity equips clinicians to diagnose and manage MDR gram-negative infections using real-world cases, rapid diagnostics, and evidence-based antimicrobial selection across acute care settings.
Target Audience
Infectious disease specialists, critical care specialists, nurse practitioners, hospital pharmacists, and clinical microbiologists.
Learning Objectives
Upon completion of the educational activity, participants should be able to:
● Demonstrate how to incorporate rapid and molecular diagnostic results into early treatment decisions for multidrug-resistant Gram-negative bacterial (MDR-GN) infections.
● Apply case-based algorithms to select targeted therapy based on diagnostic outcomes
● Explain the impact of rapid diagnostic turnaround time and accuracy on antimicrobial prescribing and stewardship outcomes
● Identify scenarios where rapid diagnostics can prevent unnecessary broad-spectrum antibiotic use
● Calculate AUC and Cmax for selected antimicrobials using clinical case data
● Adjust dosing regimens based on PK parameter interpretation to optimize efficacy and safety
● Apply PK/PD principles to tailor antibiotic dosing strategies according to bacterial strain, infection site, and patient immune status in order to optimize clinical outcomes
● Describe PK/PD targets relevant to different antibiotic classes and their role in maximizing treatment success
● Select optimal dosing strategies using PK/PD targets for MDR-GN infections in simulated cases
● Adjust antimicrobial regimens for elderly, obese, and organ-impaired patients using PK/PD principles
Get started
Criteria for Success
- To obtain a certificate of completion, a score of 70% or better on the post-test is required. Please proceed with the activity until you have successfully completed this program, answered all test questions, completed the post-test and evaluation, and have received a digital copy of your certificate. You must participate in the entire activity to receive credit. There is no fee to participate in this activity. If you have questions about this activity, please contact AKH Inc. at ketrea@akhcme.com.
https://akhcme.com/content/optimizing-outcomes-management-multidrug-resistant-gram-negative-bacterial-infections
Credit Claim Instructions
1. Click the claim link
2. Login or Create an account in the system. (All 1 st time users required to create an account)
Once complete, the course will appear in your 'Pending Activities' list, found under the 'Activities' tab on your profile page (upper right-hand corner).
3. Proceed to Register/Take Course Tab to complete the Course Evaluation & Certificate steps for the activity.
4. Click get started
- To obtain a certificate of completion, a score of 70% or better on the post-test is required. Please proceed with the activity until you have successfully completed this program, answered all test questions, completed the post-test and evaluation, and have received a digital copy of your certificate. You must participate in the entire activity to receive credit. There is no fee to participate in this activity. If you have questions about this activity, please contact AKH Inc. at ketrea@akhcme.com.
https://akhcme.com/content/optimizing-outcomes-management-multidrug-resistant-gram-negative-bacterial-infections
Credit Claim Instructions
1. Click the claim link
2. Login or Create an account in the system. (All 1 st time users required to create an account)
Once complete, the course will appear in your 'Pending Activities' list, found under the 'Activities' tab on your profile page (upper right-hand corner).
3. Proceed to Register/Take Course Tab to complete the Course Evaluation & Certificate steps for the activity.
4. Click get started
CE credit provided by AKH Inc., Advancing Knowledge in Healthcare.
In support of improving patient care, this activity has been planned and implemented by AKH Inc., Advancing Knowledge in Healthcare and Orakle LLC. AKH Inc., Advancing Knowledge in Healthcare is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
Julian de la Torre-Cisneros, MD, Infectious Diseases Service, Reina Sofia University Hospital of Córdoba, Córdoba, Spain
Matteo Bassetti, MD PhD, Director of the Infectious Diseases Clinic of the IRCCS San Martino Hospital, Genoa, Italy
Erin K. McCreary, PharmD, BCIDP, University of Pittsburgh School of Medicine
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A 64-Year-Old Woman on Long-Term Immunosuppressive Therapy Presents to the Emergency Department with Fever and Chills
A 62-Year-Old Woman with Type 2 Diabetes Presents with Acute Abdominal Pain, Fever, and Leukocytosis Following Recent Colorectal Surgery
New-Onset Fever, Productive Cough, and Hypoxia on Day 7 of Hospitalization
A 68-Year-Old Man with a History of Recurrent Urinary Tract Infections and Recent Urinary Catheterization Presents with dysuria, urgency, and frequency.
Start patient case Ms. JohnsonStart patient case Ms. KellyStart patient case Mr. XavierStart patient case Mr. AndersonPhysicians
AKH Inc., Advancing Knowledge in Healthcare designates this enduring for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Commercial Support
This activity is supported by an independent medical education grant from Pfizer.
Disclosures
Matteo Bassetti MD, PhD (faculty)
Nothing to disclose
Erin K. McCreary PharmD, BCIDP, FIDSA (faculty)
Advisor, Speaker: GSK
Julian de la Torre-Cisneros MD, PhD (faculty)
Researcher: MSD, Advanz, Qiagen, Takeda
Speaker: MSD, Shionogi, Pfizer, Menarini, Advanz, Qiagen, Takeda
Dorothy Caputo, MA, BSN, RN - President
Nothing to disclose
Michele Bielarski, RN (planner/reviewer)
Nothing to disclose
AKH Inc Staff and Planners
Nothing to disclose
Orakle LLC Staff and Planners
Nothing to disclose
Disclosures
It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The author must disclose to the participants any significant relationships with ineligible companies whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are mitigated by AKH prior to accreditation of the activity. AKH planners and reviewers have no relevant financial relationships to disclose.
Disclosure of Unlabeled Use and Investigational Product
This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Disclaimer
This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participants misunderstanding of the content. If you would like to opt out from future communications from AKH please send an email to optout@akhcme.com with your information with "Opt Out" in the subject line.
AKH Inc., Advancing Knowledge in Healthcare designates this enduring for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Commercial Support
This activity is supported by an independent medical education grant from Pfizer.
Disclosures
Matteo Bassetti MD, PhD (faculty)
Nothing to disclose
Erin K. McCreary PharmD, BCIDP, FIDSA (faculty)
Advisor, Speaker: GSK
Julian de la Torre-Cisneros MD, PhD (faculty)
Researcher: MSD, Advanz, Qiagen, Takeda
Speaker: MSD, Shionogi, Pfizer, Menarini, Advanz, Qiagen, Takeda
Dorothy Caputo, MA, BSN, RN - President
Nothing to disclose
Michele Bielarski, RN (planner/reviewer)
Nothing to disclose
AKH Inc Staff and Planners
Nothing to disclose
Orakle LLC Staff and Planners
Nothing to disclose
Disclosures
It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The author must disclose to the participants any significant relationships with ineligible companies whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are mitigated by AKH prior to accreditation of the activity. AKH planners and reviewers have no relevant financial relationships to disclose.
Disclosure of Unlabeled Use and Investigational Product
This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
Disclaimer
This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participants misunderstanding of the content. If you would like to opt out from future communications from AKH please send an email to optout@akhcme.com with your information with "Opt Out" in the subject line.
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